Transition Therapeutics Shareholders Approve Acquisition by OPKO Health

OPKO Health (Ireland)

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August 26, 2016 8:52am EDT

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MIAMI--(BUSINESS WIRE)--

OPKO Health, Inc. (Nasdaq: OPK) , announces that at a Special

Shareholder Meeting held on August 25, 2016 shareholders of Transition

Therapeutics, Inc. (NASDAQ:TTHI, TSX: TTH) holding approximately 93% of

the outstanding common shares, voted to approve the previously announced

agreement under which OPKO Health will acquire Transition Therapeutics.

The acquisition is subject to final approval of the Ontario Superior

Court Justice (the “Court”). The Court hearing for the final order is

scheduled to take place on August 29, 2016, and the acquisition is

expected to close on September 1, 2016.

“We are pleased with this vote of confidence from the Transition

Therapeutics shareholders as it underscores their confidence in our

ability to leverage the potential of Transition Therapeutics’ clinical

programs and the opportunity for shareholders of Transition Therapeutics

to participate in the continued growth and development of OPKO’s strong

pipeline,” said Phillip Frost, M.D., CEO and Chairman of OPKO Health.

“This acquisition provides OPKO with two late stage drug candidates,

each of which holds exceptional market potential and complements OPKO's

development pipeline."

About Transition Therapeutics

Transition Therapeutics is a biopharmaceutical development company

advancing novel therapeutics for CNS, metabolic diseases and androgen

deficiency indications. The company's wholly-owned

subsidiary, Transition Therapeutics Ireland Limited, has two development

programs: CNS drug candidate ELND005 for the treatment of Alzheimer's

disease and Down syndrome; and selective androgen receptor modulator

drug candidate TT701. Transition's lead metabolic drug candidate is

TT401 for the treatment of type 2 diabetes and accompanying obesity. For

additional information about the Company, please visit www.transitiontherapeutics.com .

About OPKO Health, Inc.

OPKO Health, Inc. is a diversified healthcare company that seeks to

establish industry-leading positions in large, rapidly growing markets.

Our diagnostics business includes Bio-Reference Laboratories, the

nation's third-largest clinical laboratory with a core genetic testing

business and a 420-person sales force to drive growth and leverage new

products, including the 4Kscore prostate cancer test and the Claros

1 in-office immunoassay platform. Our pharmaceutical business

features RAYALDEE , an FDA approved treatment for SHPT in stage

3-4 CKD patients with vitamin D insufficiency, and VARUBI™ for

chemotherapy-induced nausea and vomiting (oral formulation launched by

partner Tesaro and IV formulation PDUFA is January 2017). Our biologics

business includes hGH-CTP, a once-weekly human growth hormone injection

(in Phase 3 and partnered with Pfizer), a long-acting Factor VIIa drug

for hemophilia (in Phase 2a) and a long acting oxyntomodulin for

diabetes and obesity (in Phase 1). We also have production and

distribution assets worldwide, multiple strategic investments and an

active business development strategy. More information is available at www.opko.com .

Cautionary Statement Regarding Forward-Looking Statements

This press release contains "forward-looking statements," as that

term is defined under the Private Securities Litigation Reform Act of

1995 (PSLRA), which statements may be identified by words such as

"expects," "plans," "projects," "will," "may," "anticipates,"

"believes," "should," "intends," "estimates," and other words of similar

meaning, including statements regarding the timetable for completing the

proposed transaction, synergies, benefits and opportunities of the

proposed transaction, future opportunities for the combined company and

products, the potential for Transition Therapeutics’ products, the

growth, development and strength of OPKO’s pipeline,, as well as other

non-historical statements about our expectations, beliefs or intentions

regarding our business, technologies and products, financial condition,

strategies or prospects. Many factors could cause our actual activities

or results to differ materially from the activities and results

anticipated in forward-looking statements. These factors include those

described in our Annual Reports on Form 10-K filed and to be filed with

the Securities and Exchange Commission and in our other filings with the

Securities and Exchange Commission. The forward-looking statements

contained in this press release speak only as of the date the statements

were made, and we do not undertake any obligation to update

forward-looking statements. We intend that all forward-looking

statements be subject to the safe-harbor provisions of the PSLRA.

View source version on businesswire.com: http://www.businesswire.com/news/home/20160826005276/en/

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OPKO Health, Inc.

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Source: OPKO Health, Inc.

Released August 26, 2016

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