OPKO Invests in Novel Antibody Biotechnology Company

OPKO Health (Ireland)

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November 03, 2010 8:30am EDT

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MIAMI--(BUSINESS WIRE)--

OPKO Health, Inc. (NYSE Amex: OPK) announced that it has made an

investment in Fabrus, LLC, a privately held early stage biotechnology

company with next generation therapeutic antibody drug discovery and

development capabilities. In exchange for the Company's investment, the

Company acquired approximately 13% of Fabrus' outstanding membership

interests on a fully diluted basis.

"Fabrus is using its proprietary antibody screening and engineering

approach to discover promising lead compounds against several important

oncology targets," said Phillip Frost, M.D., OPKO's Chairman and Chief

Executive Officer. "We believe the Fabrus discovery approach is novel,

rapid, provides valuable data at very early discovery stages, and can

screen multiple targets or pathways in parallel. We are pleased to

secure a stake in this cutting edge company, and we look forward to

rapidly developing important drug candidates."

The Company's investment was part of a $2 million financing for Fabrus.

Other investors participating in the financing include Frost Gamma

Investments Trust, of which Phillip Frost is the sole trustee, and Hsu

Gamma Investment, L.P., of which Jane Hsiao, the Company's Vice Chairman

and Chief Technical Officer, serves as the general partner. In

connection with the financing, Drs. Frost and Hsiao will join the Fabrus

Board of Managers.

"We are pleased to have OPKO as a major shareholder in Fabrus," said Dr.

Vaughn Smider, founder of Fabrus. "Drs. Frost and Hsiao will bring

significant depth in the pharmaceutical industry to the Fabrus team."

About OPKO Health, Inc.

Miami-based OPKO is a specialty healthcare company involved in the

discovery, development, and commercialization of proprietary

pharmaceutical products, medical devices, vaccines, diagnostic

technologies and imaging systems. Initially focused on the treatment and

management of ophthalmic diseases, OPKO has since expanded into other

areas of major unmet medical need.

About Fabrus LLC

Fabrus is the first company to bring the speed and flexibility of small

molecule screening to the field of fully human antibody therapeutics,

while being unencumbered by existing antibody engineering intellectual

property. The novel discovery format is analogous to a combinatorial

chemistry library and enables direct cell based screening, opening novel

targets to antibody therapeutics like G-protein coupled receptors or ion

channels. For more information go to www.fabrus.net .

This press release contains "forward-looking statements," as that

term is defined under the Private Securities Litigation Reform Act of

1995 (PSLRA), which statements may be identified by words such as

"expects," "plans," "projects," "will," "may," "anticipates,"

"believes," "should," "intends," "estimates," and other words of similar

meaning, including statements regarding our product development efforts,

Fabrus' ability to discover promising lead compounds against several

attractive oncology targets, and our ability to rapidly develop

important drug candidates, as well as other non-historical statements

about our expectations, beliefs or intentions regarding our business,

technologies and products, financial condition, strategies or prospects.

Many factors could cause our actual activities or results to differ

materially from the activities and results anticipated in

forward-looking statements. These factors include those described in our

filings with the Securities and Exchange Commission, as well as risks

inherent in funding, developing and obtaining regulatory approvals of

new, commercially-viable and competitive products and treatments. In

addition, forward-looking statements may also be adversely affected by

general market factors, competitive product development, product

availability, federal and state regulations and legislation, the

regulatory process for new products and indications, manufacturing

issues that may arise, patent positions and litigation, among other

factors. The forward-looking statements contained in this press release

speak only as of the date the statements were made, and we do not

undertake any obligation to update forward-looking statements. We intend

that all forward-looking statements be subject to the safe-harbor

provisions of the PSLRA.

Source: OPKO Health, Inc.

Released November 3, 2010

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