OPKO Health, Inc. Set to Join Russell 3000 Index

OPKO Health (Ireland)

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June 17, 2008 9:35am EDT

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MIAMI--(BUSINESS WIRE)--

OPKO Health, Inc. (AMEX:OPK) today announced that it is set to

join the broad-market Russell 3000(R) Index when Russell Investment

Group reconstitutes its comprehensive set of U.S. and global equity

indexes on June 27, 2008, according to a preliminary membership list

posted on Friday, June 13, 2008, on its website at www.russell.com .

Membership in the Russell 3000(R), which remains in place for one

year, means OPKO would automatically be included in the small-cap

Russell 2000(R) Index, as well as appropriate growth and value style

indexes. Russell determines membership for its equity indexes

primarily by objective, market-capitalization rankings and style

attributes.

Dr. Phillip Frost, Chairman of the Board and CEO of OPKO,

commented, "We are pleased to be included in the Russell 3000 Index

and the opportunity it provides us to increase our visibility within

the investment community. We are working diligently to build a

world-class organization and OPKO's inclusion in the Russell 3000 is

another step in the growth of our company."

Russell indexes are widely used by investment managers and

institutional investors for index funds and as benchmarks for both

passive and active investment strategies. An industry-leading $4

trillion in assets currently are benchmarked to them. The Russell

3000(R), which serves as the U.S. component to the Russell Global

Index, measures the performance of the 3,000 largest U.S. companies

based on total market capitalization.

About OPKO Health, Inc.

Miami-based OPKO is a specialty healthcare company. Its lead

investigational drug, the gene silencing agent bevasiranib, is in

Phase III trials after successfully completing Phase II trials for wet

age-related macular degeneration and diabetic macular edema. OPKO is

developing a pipeline of novel agents for ophthalmic diseases, and it

markets innovative diagnostic imaging systems that complement the

company's therapeutic products. For more information visit the

company's website at www.opko.com .

This press release contains "forward-looking statements," as that

term is defined under the Private Securities Litigation Reform Act of

1995 (PSLRA), which statements may be identified by words such as

"expects," "plans," "projects," "will," "may," "anticipates,"

"believes," "should," "intends," "estimates," and other words of

similar meaning, including statements regarding our product

development efforts, our ability to develop a preclinical pipeline of

novel agents for ophthalmic diseases, as well as other non-historical

statements about our expectations, beliefs or intentions regarding our

business, technologies and products, financial condition, strategies

or prospects. Many factors could cause our actual activities or

results to differ materially from the activities and results

anticipated in forward-looking statements. These factors include those

described in our filings with the Securities and Exchange Commission,

as well as risks inherent in funding, developing and obtaining

regulatory approvals of new, commercially viable and competitive

products and treatments. In addition, forward-looking statements may

also be adversely affected by general market factors, competitive

product development, product availability, federal and state

regulations and legislation, the regulatory process for new products

and indications, manufacturing issues that may arise, patent positions

and litigation, among other factors. The forward-looking statements

contained in this press release speak only as of the date the

statements were made, and we do not undertake any obligation to update

forward-looking statements. We intend that all forward-looking

statements be subject to the safe-harbor provisions of the PSLRA.

Source: OPKO Health, Inc.

Released June 17, 2008

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