OPKO Health Announces New Listing on Tel Aviv Stock Exchange

OPKO Health (Ireland) · Nesher, Israel

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August 19, 2013 7:00am EDT

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—Shares already listed on NYSE and will also list on the TASE

beginning August 21— under Ticker Symbol OPK

MIAMI & TEL AVIV, Israel--(BUSINESS WIRE)--

OPKO Health, Inc. (NYSE: OPK), a multi-national biopharmaceutical and

diagnostics company, today announced that the Tel-Aviv Stock Exchange

(“TASE”) has approved the new listing of OPKO’s common stock on the TASE

beginning on August 21, 2013, under the ticker symbol OPK. OPKO’s common

stock will thereafter be listed on both the NYSE in the United States

and the TASE in Israel. Based on OPKO’s market capitalization, OPKO

expects its shares to be included in the TA-25 Index (TA-25), the TASE

flagship index which tracks the share prices of the 25 companies with

the highest market capitalization on the exchange.

“We are very pleased to welcome OPKO, a biopharmaceutical and diagnostic

company which is active around the world, to the Tel-Aviv Stock

Exchange, and its entry into the leading indexes of TASE,” said Ester

Levanon, CEO of the Tel-Aviv Stock Exchange. “Over the past few years

TASE has become a center for biomed companies. The registration of OPKO

on TASE demonstrates a vote of confidence in the Israeli stock market

and the leading position of the biomed sector on TASE. By virtue of its

dual listing, OPKO will enjoy significant advantages, including exposure

to Israeli investors, expanded trading hours, investment by way of

index-based instruments, exchange traded notes and funds and specialized

funds, and easy access to institutional and private investors and

emerging global companies.”

“We are pleased to start trading on the TASE with this dual listing and

to join Israel’s top companies as part of the TA-25 index,” commented

Dr. Phillip Frost, OPKO’s Chairman and Chief Executive Officer. “We

believe that this step will expand our exposure to the Israeli

investment community and will increase the interest in OPKO among

Israel’s large and sophisticated institutional investors. We already

have a significant presence in Israel through our ownership of FineTech

Pharmaceuticals Ltd, based in Nesher, Israel, which is engaged in the

development and production of high-value, high-potency specialty active

pharmaceutical ingredients, and a controlling interest in Sci-Vac Ltd,

which manufactures and sells a third-generation hepatitis B vaccine

produced in a state of the art biologics manufacturing facility in

Rehovot, Israel. We expect that Israel will become OPKO’s biotechnology

R&D global center upon completion of our pending acquisition of PROLOR

Biotech, Inc., a biopharmaceutical company based in Nes Ziona, Israel

that is applying unique technologies to develop and commercialize

longer-acting proprietary versions of already approved therapeutic

proteins.”

OPKO will remain subject to the rules and regulations of the NYSE and of

the U.S. Securities and Exchange Commission. Trading on the TASE occurs

on Sunday from 9:45 AM to 4:30 PM Israel time and on Monday through

Thursday from 9:45 AM to 5:30 PM Israel time, except on TASE trading

holidays. Through the amendment to Israel’s Securities Law 5728-1968,

that took effect in October 2000, U.S.-listed companies may dual-list on

the TASE without any additional regulatory requirements. TASE links to

the U.S. markets via a direct link to DTC, a subsidiary of the

Depository Trust & Clearing Corporation, which facilitates the trading

of dually-listed securities.

ABOUT OPKO HEALTH, INC.

OPKO is a multinational biopharmaceutical and diagnostics company that

seeks to establish industry leading positions in large, rapidly growing

markets by leveraging its discovery, development and commercialization

expertise and novel and proprietary technologies. For more information,

visit http://www.opko.com .

SAFE HARBOR STATEMENT

This press release includes forward looking statements, within the

meaning of the Private Securities Litigation Reform Act of 1995, which

are subject to risk and uncertainties that could cause actual results to

differ materially from those anticipated. Such statements may relate to

OPKO’s plans, objectives and expected financial and operating results,

including statements regarding our ability to expand our exposure to the

Israeli investment community and increase interest in OPKO among

Israel’s large and sophisticated institutional investors. The words

"may," "could," "would," “will,” "believe," "anticipate," "estimate,"

"expect," "intend," "plan," and similar expressions or variations

thereof are intended to identify forward-looking statements. Investors

are cautioned that any such forward-looking statements are not

guarantees of future performance and involve risks and uncertainties,

many of which are beyond OPKO’s ability to control. The risks and

uncertainties that may affect forward looking statements include, but

are not limited to: currency fluctuations, global economic and political

conditions, marketing demand for OPKO’s products and services, long

sales cycles, new product development, assimilating future acquisitions,

maintaining relationships with customers and partners, and increased

competition, as well as the risk we may not complete the acquisition of

PROLOR Biotech, Inc. For more details about the risks and uncertainties

related to OPKO’s business, refer to OPKO’s filings with the Securities

and Exchange Commission. OPKO undertakes no obligation to publicly

update or revise any forward looking statements, whether as a result of

new information, future events or otherwise.

OPKO Heath, Inc.

Steve D. Rubin

Executive Vice President –

Administration

or

Juan F. Rodrigez

Chief Financial Officer

Source: OPKO Health, Inc.

Released August 19, 2013

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