OPKO Health Announces Listing in Major Indices on Tel Aviv Stock Exchange

OPKO Health (Ireland)

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August 28, 2013 8:25am EDT

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Provides Broader Access to Israeli Investors for Shares already

listed on NYSE and TASE under Ticker Symbol OPK

MIAMI--(BUSINESS WIRE)--

OPKO Health, Inc. (NYSE: OPK), a multi-national biopharmaceutical and

diagnostics company, today announced that OPKO's common stock, which

began trading on the Tel-Aviv Stock Exchange ("TASE") on August 21,

2013, will be included, effective October 6, 2013, in the following

major TASE indices: Tel Aviv 25, Tel Aviv 100, Tel Aviv Composite, Tel

Aviv Biomed, and Tel Aviv BlueTech-50.

“OPKO’s inclusion in these major TASE indices expands our exposure to

Israel’s vibrant investment community and its large and sophisticated

investors,” commented Dr. Phillip Frost, OPKO’s Chairman and Chief

Executive Officer. “Our participation in these major indices conveys

broader coverage through index-based instruments, exchange traded notes,

funds and specialized funds, while providing easier access to

institutional and private investors within the Israeli market."

OPKO will remain subject to the rules and regulations of the NYSE and of

the U.S. Securities and Exchange Commission. Trading on the TASE occurs

on Sunday from 9:45 AM to 4:30 PM Israel time and on Monday through

Thursday from 9:45 AM to 5:30 PM Israel time, except on TASE trading

holidays. Through the amendment to Israel's Securities Law 5728-1968,

that took effect in October 2000, U.S.-listed companies may dual-list on

the TASE without any additional regulatory requirements. TASE links to

the U.S. markets via a direct link to DTC, a subsidiary of the

Depository Trust & Clearing Corporation, which facilitates the trading

of dually-listed securities.

ABOUT OPKO HEALTH, INC.

OPKO is a multinational biopharmaceutical and diagnostics company that

seeks to establish industry leading positions in large, rapidly growing

markets by leveraging its discovery, development and commercialization

expertise and novel and proprietary technologies. For more information,

visit http://www.opko.com .

SAFE HARBOR STATEMENT

This press release includes forward looking statements, within the

meaning of the Private Securities Litigation Reform Act of 1995, which

are subject to risk and uncertainties that could cause actual results to

differ materially from those anticipated. Such statements may relate to

OPKO's plans, objectives and expected financial and operating results,

including statements regarding our ability to expand our exposure to the

Israeli investment community and increase interest in OPKO among

Israel's large and sophisticated institutional investors. The words

"may," "could," "would," "will," "believe," "anticipate," "estimate,"

"expect," "intend," "plan," and similar expressions or variations

thereof are intended to identify forward-looking statements. Investors

are cautioned that any such forward-looking statements are not

guarantees of future performance and involve risks and uncertainties,

many of which are beyond OPKO's ability to control. The risks and

uncertainties that may affect forward looking statements include, but

are not limited to: currency fluctuations, global economic and political

conditions, marketing demand for OPKO's products and services, long

sales cycles, new product development, assimilating future acquisitions,

maintaining relationships with customers and partners, and increased

competition, as well as the risk we may not complete the acquisition of

PROLOR Biotech, Inc. For more details about the risks and uncertainties

related to OPKO's business, refer to OPKO's filings with the Securities

and Exchange Commission. OPKO undertakes no obligation to publicly

update or revise any forward looking statements, whether as a result of

new information, future events or otherwise.

OPKO Heath, Inc.

Steve D. Rubin, +1-305-575-4100

Executive

Vice President — Administration

or

Juan F. Rodriguez,

Chief Financial Officer

Source: OPKO Heath, Inc.

Released August 28, 2013

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