OPKO Adds to Growing Technology Portfolio Through Strategic Investment in Biotechnology Company Engaged in the Development of a New Generation of Antibodies

OPKO Health (Ireland)

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October 10, 2013 9:00am EDT

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MIAMI--(BUSINESS WIRE)--

OPKO Health, Inc. (NYSE: OPK) has agreed to make an investment in Zebra

Biologics, Inc. (“Zebra”), a privately held biotechnology company

focused on the discovery and development of biosuperior antibody

therapeutics and complex drug targets. Zebra’s patented platform is an

advanced version of a core technology that underlies the discovery and

commercial success of AbbVie Inc.’s Humira ™, developed by Richard

Lerner, M.D., at The Scripps Research Institute. The technology allows

for the selection of antibodies for function rather than through simple

binding. Zebra has already developed an early pre-clinical pipeline of

candidate antibodies with significant commercial potential in regulating

diabetes and obesity, cancer, and treatment of neurological disease.

In addition to Phillip Frost, M.D., OPKO’s Chairman and Chief Executive

Officer, Zebra’s directors and founders also include Dr. Lerner; Dr.

Ronald M. Lindsay, a director and Executive Vice President for Strategic

Planning of Sequenom, Inc. (NASDAQ: SQNM), a company providing

innovative diagnostic testing and genetic analysis solutions; Mr. Gao

Feng, chairman and president of Beijing based Hongye International

Investment Group, which operates in the energy, natural resources,

finance and bio-pharmaceuticals industries; and Dr. Paul Greengard,

Vincent Astor Professor at Rockefeller University and recipient of a

2000 Nobel Prize for his work concerning signal transduction in the

nervous system.

“This participation is in keeping with a core strategy of investing in

other companies that have valuable proprietary technology and

significant future potential for OPKO,” said Dr. Frost. “We are hopeful

that our portfolio of investments will continue to appreciate in value

as the companies and technologies mature. In some cases, our investments

offer opportunities for OPKO to obtain new products; as well as the

possibility to monetize them at an appropriate time.”

ABOUT OPKO HEALTH, INC.

OPKO is a multinational biopharmaceutical and diagnostics company that

seeks to establish industry leading positions in large, rapidly growing

markets by leveraging its discovery, development and commercialization

expertise and novel and proprietary technologies. For more information,

visit http://www.opko.com .

SAFE HARBOR STATEMENT

This press release includes forward looking statements, within the

meaning of the Private Securities Litigation Reform Act of 1995, which

are subject to risks and uncertainties that could cause actual results

to differ materially from those anticipated. Such statements may relate

to OPKO's plans, objectives and expected financial and operating

results, including statements regarding the commercial potential of

Zebra’s early pre-clinical pipeline of candidate antibodies, expected

benefits from OPKO’s investment in Zebra and other companies with

valuable proprietary technology, the value of OPKO’s portfolio of

investments and whether the investments will continue to appreciate in

value, whether the investments offer opportunities for new products, and

whether OPKO will be able to monetize the investments at the appropriate

time. The words "may," "could," "would," "will," "believe,"

"anticipate," "estimate," "expect," "intend," "plan," and similar

expressions or variations thereof are intended to identify

forward-looking statements. Investors are cautioned that any such

forward-looking statements are not guarantees of future performance and

involve risks and uncertainties, many of which are beyond OPKO's ability

to control. The risks and uncertainties that may affect forward looking

statements include those described in OPKO’s filings with the Securities

and Exchange Commission, as well as risks inherent in funding,

developing and obtaining regulatory approvals of new,

commercially-viable and competitive products and treatments, general

market factors, competitive product development, product availability,

federal and state regulations and legislation, the regulatory process

for new products and indications, manufacturing issues that may arise,

patent positions and litigation, among other factors For more details

about the risks and uncertainties related to OPKO's business, refer to

OPKO's filings with the Securities and Exchange Commission. OPKO

undertakes no obligation to publicly update or revise any forward

looking statements, whether as a result of new information, future

events or otherwise.

OPKO Health, Inc.

Steve D. Rubin, 305-575-4100

Executive Vice

President — Administration

or

Juan F. Rodriguez, 305-575-4100

Chief

Financial Officer

Source: OPKO Health, Inc.

Released October 10, 2013

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